Preclinical/Clinical Evidence

A number of research studies support the use of V.A.C. VERAFLO™ Therapy. Click on a study title to download (if available) or request a copy.

Preclinical studies

Lessing MC, James RB, Ingram SC. Comparison of the effects of different negative pressure wound therapy modes—continuous, noncontinuous, and with instillation—on porcine excisional wounds. Eplasty. 2013;13:e51. Published online 2013 Oct 1.

Rycerz AM, Allen D, Lessing MC. Science supporting negative pressure wound therapy with instillation. Int Wound J. 2013;10(suppl 1):20-24.

Lessing MC, Slack P, Hong KZ, et al. Negative pressure wound therapy with controlled saline instillation (NPWTi): dressing properties and granulation response in vivo. Wounds. 2011;23(10):309-319.

Clinical studies

McKanna, Geraci, Hall, et al. Clinical panel recommendations for use of negative pressure wound therapy with instillation. Wounds. 2016;16(4):Suppl 1-14.

Kim PJ, Attinger CE, Oliver N, et al. Comparison of outcomes for normal saline and an antiseptic solution for negative pressure wound therapy with instillation. Plast Reconstr Surg. 2015;136:657e-664e.

Kim PJ, Attinger CE, Crist BD, et al. Negative pressure wound therapy with instillation: review of evidence and recommendations. Wounds. 2015;27(12):Suppl 1-20.

Gupta S, Gabriel A, Lantis J, Téot L. Clinical recommendations and practical guide for negative pressure wound therapy with instillation. Int Wound J. 2015; doi: 10.1111/iwj.12452

Kim PJ, Attinger CE, Steinberg JS, et al. The impact of negative pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study. Plast Reconstr Surg. 2014;133:709–716.
Abstract available; for the complete study, please request a copy using the form below.

Gabriel A, Kahn K, Karmy-Jones R. Use of negative pressure wound therapy with automated, volumetric instillation for the treatment of extremity and trunk wounds: clinical outcomes and potential cost-effectiveness. Eplasty. 2014;14:e41. Published online Nov. 3, 2014.

Gabriel A, Rauen B. Simplified negative pressure wound therapy with instillation: advances and recommendations. Plast Surg Nurs. 2014;34(2):88-92.
Abstract available; for the complete study, please request a copy using the form below.

Gabriel A, Kahn M. New advances in instillation therapy in wounds at risk for compromised healing. Surg Technol Int. 2014;24:75-81.
Abstract available; for the complete study, please request a copy using the form below.

Brinkert D, Mazen A, Naud M, et al. Negative pressure wound therapy with saline instillation: 131 patient case series. Int Wound J. 2013;10(suppl 1):56-60.

Kim PJ, Attinger CE, Steinberg JS, et al. Negative-pressure wound therapy with instillation: international consensus guidelines. Plast Reconstr Surg. 2013 Dec;132(6):1569-1579.
Abstract available; for the complete study, please request a copy using the form below.

Gabriel A. Integrated negative pressure wound therapy with volumetric automated fluid instillation in wounds at risk for compromised healing. Int Wound J. 2012;9(suppl 1):25-31.

Teot L., Boissiere F., Fluieraru, S. Novel foam dressing using negative pressure wound therapy with instillation to remove thick exudate International Wound Journal 2017; 10:1111/iwj.12719.

Please check the box next to the study titles you would like to receive a copy of and provide your information in the fields below. A PDF version of each study you requested will be emailed to you within 3 days.

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